That fact distinguishes them from the norepinephrine selective reuptake inhibitors (NSRIs) (e.g., desipramine) and from the selective serotonin reuptake inhibitors (SSRIs) (e.g., sertraline) (Figure 2).
I was actually hoping for a better answer to be true did you notice less sedation on the higher dosage ? It's quite weird your were unemotional as mirtazapine blocks serotonin receptors so it should have let dopamine flow into various areas of the brain and give back emotions . I was on 2 ssri's that persistently desensitized the serotonin receptor even after quitting it so now more serotonin is flowing into various other area's of the brain and so my libido was gone and still is after 2 years ....
and also my dopamine is downregulated that gave me ahnedonia (excessive porn and after ejactuation 3 times in a row - everything swtiched off) I am looking to block Most serotonin receptor esp the 5htia , 5ht2c and 5ht2a so that it can get to pre ssri state and let other major transmitter like dopamine flow freely ... For me, 30 mgs actually increased my anxiety so I couldn't use it as a stand alone AD. It's really not all that great as a 5ht antagonist, except on the 5ht1a receptor, probably one of the reasons it made me more anxious.
Mirtazapine is a newer antidepressant that exhibits both noradrenergic and serotonergic activity.
It is at least as effective as the older antidepressants for treating mild to severe depression. Although agranulocytosis is the most serious side effect, it is rare (approximately one in 1,000) and usually reversible when the medication is stopped. Many clinicians consider mirtazapine a second-line or even third-line antidepressant, to be used when older antidepressants are not tolerated or are ineffective.
Mirtazapine also appears to be useful in patients with depression who present with anxiety symptoms and sleep disturbances Holm and Markham (1999).
Mirtazapine is rapidly absorbed from the gastro-intestinal tract with peak plasma concentrations reached within about two hours after an oral dose.
Mirtazapine is an analogue of mianserin, it is a piperazinoazepine and has a tetracyclic chemical structure unrelated to selective serotonin-reuptake inhibitors, tricyclics, or monoamine oxidase inhibitors Sweetman et al (2002).
It is the first noradrenergic and specific serotonergic antidepressant (“Na SSA”), and is used for more severe forms of the disorder Holm and Markham (1999).
It enhances central noradrenergic and serotonergic activity by blocking alpha10Mirtazapine is well absorbed without regard to food intake.
It demonstrates linear kinetics over its usual dosage range and reaches peak plasma level approximately two hours after an oral dose.11 The elimination half-life is 20 to 40 hours, so a steady state is reached in approximately five days.
This series of planes, first rolled out in the 1950s, are still being used.